Paul Ritter: A deeper insight into muscular diseases

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Paul preparing the tissue sample

Duchenne Muscular Dystrophy, abbreviated as DMD, is a genetic muscular disease causing inflammations, reduced membrane stability and ongoing myatrophy. To understand and assess the causes and effects of this incurable disease, different mouse model systems are investigated for quite some time now.

Paul Ritter complements these efforts with a pioneering structure-function analysis using 3D characterization of single muscle fibers. He concludes that the intracellular remodeling is another reliable parameter to judge the progress of DMD, supplementing the current assessment of muscular fibrosis only. Further details on the methods and results are found in Paul’s latest publication, Myofibrillar Lattice Remodeling Is a Structural Cytoskeletal Predictor of Diaphragm Muscle Weakness in a Fibrotic mdx (mdx Cmah−/−) Model.

Paul works at the Institute of Medical Biotechnology, his supervisor is Oliver Friedrich. The original publication can be found in the International Journal of Molecular Sciences.

Close up of the sample preparation
A sample on the multi-photon microscopy stage